Abstract: In this paper, we investigate the asymptotic performance of timing acquisition systems having fixed dwell time in multipath fading channels. We isolate the detrimental effect of the multipath channel fading on the acquisition performance by considering the asymptotic performance as the average signal-to-noise ratio (SNR) increases without bound. We find that for any threshold such that the average probability of false alarm is less than a given tolerance, the channel fading results in a lower bound on the asymptotic average probability of miss which is non-trivial for a variety of fading scenarios. We consider a threshold-based direct-sequence spread-spectrum signal acquisition system and find that the detrimental effect of channel fading on asymptotic acquisition performance, albeit non-trivial, is not very significant. On the contrary, for threshold-based ultra-wideband signal acquisition systems, the detrimental effect of channel fading is significant for both signals with direct-sequence and time-hopping spreading, and is found to be worse in the latter case.